1,3-二邻甲苯基胍 — 登记平台物质详情

① 化学品基本信息

化学品名称

1,3-二邻甲苯基胍

英文名称

1,3-di-o-tolylguanidine

CAS号

97-39-2

② 标签要素

危险性类别

急性毒性-经口,类别3,严重眼损伤/眼刺激,类别2A,生殖毒性,类别2,特异性靶器官毒性-一次接触,类别1,特异性靶器官毒性-反复接触,类别2,危害水生环境-急性危害,类别2

GHS警示词

危险

GHS分类来源

自分类

象形图

GHS06

GHS08

危险性说明

H301:吞咽会中毒H319:造成严重眼刺激H361:怀疑对生育能力或胎儿造成伤害（如果已知，说明特异性效应；如果确证无其他接触途径引起危害，说明接触途径）H370:对器官造成损害（如果知道，说明所受损的器官）（如果可确证无其他接触途径引起危害，说明接触途径）H373:长时间或反复接触（如果可确证无其他接触途径引起该危害，说明接触途径）可能对器官造成伤害（如果已经知道，说明所受损害的器官）H401:对水生生物有毒

③ 理化特性

外观与性状

白色粉末。

熔点（℃）

179

饱和蒸气压（kPa）

0

辛醇/水分配系数（LogKow）

2.9 (25 °C)

闪点（℃）

205.48

溶解性

略溶于热水、酒精；易溶于乙醚；氯仿溶胶。

密度

1.10 @ 20 DEG C/4 DEG C[Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-323] **PEER REVIEWED**

④ 危害信息

活性反应

一般作业时，无需要特别关注的危险反应。

禁配物

无资料。

中毒表现

吞咽会中毒，造成严重眼刺激，怀疑对生育能力或胎儿造成伤害（如果已知，说明特异性效应；如果确证无其他接触途径引起危害，说明接触途径），对器官造成损害（如果知道，说明所受损的器官）（如果可确证无其他接触途径引起危害，说明接触途径），长时间或反复接触（如果可确证无其他接触途径引起该危害，说明接触途径）可能对器官造成伤害（如果已经知道，说明所受损害的器官）。

环境危害

对水生生物有毒。

⑤ 应急处置措施

急救措施

A) DECONTAMINATION - 1) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm. B) IRRITATION - 1) Respiratory tract irritation, if severe, can progress to pulmonary edema which may be delayed in onset up to 24 to 72 hours after exposure in some cases. C) ACUTE LUNG INJURY - 1) ACUTE LUNG INJURY: Maintain ventilation and oxygenation and evaluate with frequent arterial blood gases and/or pulse oximetry monitoring. Early use of PEEP and mechanical ventilation may be needed. D) BRONCHOSPASM - 1) If bronchospasm and wheezing occur, consider treatment with inhaled sympathomimetic agents. E) OBSERVATION CRITERIA - 1) Carefully observe patients with inhalation exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary. 2) Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved.A) GASTRIC LAVAGE 1) Significant esophageal or gastrointestinal tract irritation or burns may occur following ingestion. The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. 2) GASTRIC LAVAGE: Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Protect airway by placement in the head down left lateral decubitus position or by endotracheal intubation. Control any seizures first. a) CONTRAINDICATIONS: Loss of airway protective reflexes or decreased level of consciousness in unintubated patients; following ingestion of corrosives; hydrocarbons (high aspiration potential); patients at risk of hemorrhage or gastrointestinal perforation; and trivial or non-toxic ingestion. B) ACTIVATED CHARCOAL 1) Activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. In general, metals and acids are poorly bound and patients ingesting these materials will not likely benefit from activated charcoal administration. a) Activated charcoal should not be given to patients ingesting strong acidic or basic caustic chemicals. Activated charcoal is also of unproven value in patients ingesting irritant chemicals, where it may obscure endoscopic findings when the procedure is justified. 2) ACTIVATED CHARCOAL: Administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old. C) DILUTION - 1) Immediate dilution with milk or water may be of benefit in caustic or irritant chemical ingestions. 2) DILUTION: If no respiratory compromise is present, administer milk or water as soon as possible after ingestion. Dilution may only be helpful if performed in the first seconds to minutes after ingestion. The ideal amount is unknown; no more than 8 ounces (240 mL) in adults and 4 ounces (120 mL) in children is recommended to minimize the risk of vomiting. D) IRRITATION - 1) Observe patients with ingestion carefully for the possible development of esophageal or gastrointestinal tract irritation or burns. If signs or symptoms of esophageal irritation or burns are present, consider endoscopy to determine the extent of injury. E) OBSERVATION CRITERIA - 1) Carefully observe patients with ingestion exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary. 2) Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved.A) OVERVIEW 1) DERMAL DECONTAMINATION - a) DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999). 2) PESTICIDES - a) DECONTAMINATION: Remove contaminated clothing and jewelry and place them in plastic bags. Wash exposed areas with soap and water for 10 to 15 minutes with gentle sponging to avoid skin breakdown. A physician may need to examine the area if irritation or pain persists (Burgess et al, 1999). 3) IRRITATION - a) Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines. 4) DERMAL ABSORPTION - a) Some chemicals can produce systemic poisoning by absorption through intact skin. Carefully observe patients with dermal exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

泄漏应急处理

用洁净的铲子收集泄漏物,置于干净、干燥、盖子较松的容器中,将容器移离泄漏区。

灭火方法

消防人员须佩戴正压式消防空气呼吸器，可能接触化学品的应穿消防员一级化学防护服，在上风向灭火。喷水冷却容器，可能的话将容器从火场移至空旷处。处在火场中的容器若已变色或产生异常声音，必须马上撤离。避免使用直流水冲击堆垛。盛装容器材质不能与泄漏化学品发生反应。

⑥ 安全技术说明书

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