对甲基苯磺酸,对甲苯磺酸,4-甲苯磺酸,甲苯-4-磺酸；对甲基苯磺酸；对甲苯磺酸；4-甲苯磺酸；甲苯-4-磺酸
CAS 104-15-4
P-TOLUENESULFONIC ACID
① 化学品基本信息
化学品名称
对甲基苯磺酸,对甲苯磺酸,4-甲苯磺酸,甲苯-4-磺酸；对甲基苯磺酸；对甲苯磺酸；4-甲苯磺酸；甲苯-4-磺酸
英文名称
P-TOLUENESULFONIC ACID
CAS号
104-15-4
法规目录列入情况 命中 1 项
危险货物品名表
② 标签要素
危险性类别
皮肤腐蚀/刺激,类别2,严重眼损伤/眼刺激,类别2,特异性靶器官毒性-一次接触,类别3（呼吸道刺激）
GHS警示词
警告
GHS分类来源
自分类
象形图
GHS07
危险性说明
H315:造成皮肤刺激H319:造成严重眼刺激H335:可能引起呼吸道刺激
③ 理化特性
外观与性状
无色吸湿的薄片。
熔点（℃）
106～107
沸点/沸程（℃）
140，20 MM HG
相对密度（水=1）
1.24
相对蒸气密度（空气=1）
无资料
饱和蒸气压（kPa）
约 3.3 (约 35 °C)
辛醇/水分配系数（LogKow）
0.9（计算值）
闪点（℃）
184（闭杯）
自燃温度（℃）
> 465 (约 1 atm)
爆炸下限（%）
无资料
爆炸上限（%）
无资料
溶解性
易溶，25℃
密度
1345 (20 °C)
④ 危害信息
燃烧与爆炸危险性
火灾：可燃的。在火焰中释放出刺激性或有毒烟雾（或气体）。 化学危险性：加热时或燃烧时，该物质分解生成含有硫氧化物的有毒和腐蚀性烟雾。该物质是一种强酸，与碱激烈反应并有腐蚀性。浸蚀许多金属，生成易燃/爆炸性气体氢（见卡片#0001）。
活性反应
火灾：可燃的。在火焰中释放出刺激性或有毒烟雾（或气体）。
禁配物
氧化剂、卤素、碱类、活性金属粉末。
中毒表现
吸入后会：咽喉痛。咳嗽。灼烧感。呼吸困难。呼吸短促。 皮肤接触后会：发红。疼痛。严重皮肤烧伤。 眼睛接触后会：发红。疼痛。烧伤。 食入会：咽喉疼痛。咽喉和胸腔灼烧感。休克或虚脱。 短期接触的影响：该物质腐蚀眼睛，皮肤和呼吸道。食入有腐蚀性。吸入气溶胶可能引起肺水肿（见注解）。需进行医学观察。
职业接触限值
阈限值未制定标准。最高容许浓度未制定标准。
环境危害
该物质对水生生物是有害的。
⑤ 应急处置措施
急救措施
A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm. B) INHALATION: Administer oxygen. If respiratory symptoms develop obtain chest x-ray, monitor pulse oximetry and/or blood gases. Treat bronchospasm with inhaled beta2-adrenergic agonists. If acute lung injury develops, consider PEEP. Evaluate for esophageal, dermal and eye burns as indicated.A) MANAGEMENT OF MILD TO MODERATE ORAL TOXICITY 1) Within the first 12 hours of exposure, if burns are absent or grade I severity, patient may be discharged when able to tolerate liquids and soft foods by mouth. If mild grade II burns, admit for intravenous fluids, slowly advance diet as tolerated. Perform barium swallow or repeat endoscopy several weeks after ingestion (sooner if difficulty swallowing) to evaluate for stricture formation. B) MANAGEMENT OF SEVERE ORAL TOXICITY 1) Resuscitate with 0.9% saline; blood products may be necessary. Early airway management in patients with upper airway edema or respiratory distress. Early (within 12 hours) gastrointestinal endoscopy to evaluate for burns. Early bronchoscopy in patients with respiratory distress or upper airway edema. Early surgical consultation for patients with severe grade II or grade III burns, large deliberate ingestions, or signs, symptoms or laboratory findings concerning for tissue necrosis or perforation. C) DECONTAMINATION 1) INGESTION: In patients without vomiting or respiratory distress who are able to swallow, dilute with 4-8 ounces milk/water if possible shortly after ingestion; then NPO until after endoscopy. Neutralization, gastric lavage, and activated charcoal are all contraindicated. OCULAR: Copious irrigation until pH neutral. DERMAL: Remove contaminated clothes, brush off particulate corrosives, follow with copious irrigation. INHALATION: Humidified oxygen. D) AIRWAY MANAGEMENT 1) Aggressive airway management in patients with deliberate ingestions or any indication of upper airway injury. Severe edema may make intubation difficult; be prepared for surgical airway management (cricothyroidotomy) in patients with severe upper airway edema. E) ENDOSCOPY 1) Should be performed as soon as possible (preferably within 12 hours, not more than 24 hours) in any patient with acid ingestion. The grade of mucosal injury at endoscopy is the strongest predictive factor for the occurrence of systemic and GI complications and mortality. The absence of visible oral burns does NOT reliably exclude the presence of esophageal or gastric burns. F) BRONCHOSPASM 1) Treat with oxygen, inhaled beta agonists and consider systemic corticosteroids. G) CORTICOSTEROIDS 1) The use of corticosteroids to prevent stricture formation is controversial. Corticosteroids should not be used in patients with grade I or grade III injury, as there is no evidence that it is effective. Evidence for grade II burns is conflicting, and the risk of perforation and infection is increased with steroid use, so routine use is not recommended. H) STRICTURE 1) A barium swallow or repeat endoscopy should be performed several weeks after ingestion in any patient with grade II or III burns or with difficulty swallowing to evaluate for stricture formation. Recurrent dilation may be required. Some authors advocate early stent placement in these patients to prevent stricture formation. I) SURGICAL MANAGEMENT 1) Immediate surgical consultation should be obtained on any patient with grade III or severe grade II burns on endoscopy, significant abdominal pain, metabolic acidosis, hypotension, coagulopathy, or a history of large ingestion. Early laparotomy can identify tissue necrosis and impending or unrecognized perforation, early resection and repair in these patients is associated with improved outcome. J) EYE INJURY 1) Copious irrigation until pH neutral; perform slit lamp exam. Ophthalmology consult. Antibiotics and mydriatics may be indicated. K) PATIENT DISPOSITION 1) OBSERVATION CRITERIA: Patients with an acid ingestion should be sent to a health care facility for evaluation. Patients with an endoscopic evaluation that demonstrates no burns or only minor grade I burns and who can tolerate oral intake can be discharged to home. 2) ADMISSION CRITERIA: Symptomatic patients, and those with endoscopically demonstrated grade II or higher burns should be admitted. Patients with respiratory distress, grade III burns, or extensive grade II burns, acidosis, hemodynamic instability, gastrointestinal bleeding, or large ingestions should be admitted to an intensive care setting. L) PITFALLS 1) The absence of oral burns does NOT reliably exclude the possibility of significant esophageal burns. 2) Patients may have severe tissue necrosis and impending perforation requiring early surgical intervention without having severe hypotension, rigid abdomen, or radiographic evidence of intraperitoneal air. 3) Patients with any evidence of upper airway involvement require early airway management before airway edema progresses. 4) The extent of eye injury (degree of corneal opacification and perilimbal whitening) may not be apparent for 48 to 72 hours after the burn. All patients with acidic eye injury should be evaluated by an ophthalmologist. M) DIFFERENTIAL DIAGNOSIS 1) Alkaline corrosive ingestion, gastrointestinal hemorrhage, or perforated viscus.A) OVERVIEW 1) DECONTAMINATION: Remove contaminated clothing and jewelry and irrigate exposed areas with copious amounts of water. A physician may need to examine the area if irritation or pain persists.A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility. B) CAUSTIC EYE DECONTAMINATION: Immediately irrigate each affected eye with copious amounts of water or sterile 0.9% saline for about 30 minutes. Irrigating volumes up to 20 L or more have been used to neutralize the pH. After this initial period of irrigation, the corneal pH may be checked with litmus paper and a brief external eye exam performed. Continue direct copious irrigation with sterile 0.9% saline until the conjunctival fornices are free of particulate matter and returned to pH neutrality (pH 7.4). Once irrigation is complete, a full eye exam should be performed with careful attention to the possibility of perforation. C) EYE ASSESSMENT: The extent of eye injury (degree of corneal opacification and perilimbal whitening) may not be apparent for 48 to 72 hours after the burn.
泄漏应急处理
小量泄漏:用砂土或其他不燃材料吸收。使用洁净的无火花工具收集吸收材料。大量泄漏:构筑围堤或挖坑收容。用泡沫覆盖,减少蒸发。用防爆泵转移至槽车或专用收集器内。
灭火方法
火灾：干粉，抗溶性泡沫，雾状水，二氧化碳。 爆炸：着火时，喷雾状水保持料桶等冷却。
⑥ 安全技术说明书
该物质在登记平台未登记 SDS 文件。
平台未登记 SDS
数据来源：应急管理部化学品登记中心 · 国家危险化学品安全公共服务互联网平台（whpdj.mem.gov.cn）