邻甲苯基缩水甘油醚 — 登记平台物质详情

① 化学品基本信息

化学品名称

邻甲苯基缩水甘油醚

英文名称

Oxirane, 2-[(methylphenoxy)methyl]-

CAS号

26447-14-3

② 标签要素

危险性类别

皮肤腐蚀/刺激,类别2,皮肤致敏物,类别1,生殖细胞致突变性,类别2,危害水生环境-急性危害,类别2,危害水生环境-长期危害,类别2

GHS警示词

警告

GHS分类来源

自分类

象形图

GHS07

GHS08

GHS09

危险性说明

H315:造成皮肤刺激H317:可能导致皮肤过敏反应H341:怀疑可造成遗传性缺陷（如果最终证明没有其他接触途径会产生这一危害时，应说明其接触途径）H411:对水生生物有毒并具有长期持续影响

③ 理化特性

外观与性状

透明无色液体。

熔点（℃）

无资料

沸点/沸程（℃）

170 ～ 195，100 mbar

相对密度（水=1）

1.09，68 ° F(USCG, 1999)

相对蒸气密度（空气=1）

无资料

饱和蒸气压（kPa）

0.0057，25℃ (估算)

燃烧热（kJ/mol）

-6305280

辛醇/水分配系数（LogKow）

2.16 (估算)

闪点（℃）

93.33 (开杯)

自燃温度（℃）

无资料

爆炸下限（%）

无资料

爆炸上限（%）

无资料

溶解性

微溶于水，25℃ 估算)

密度

1.14，25℃

④ 危害信息

活性反应

与强氧化剂接触，有发生火灾和爆炸的危险。

禁配物

/Cresyl glycidyl ether/ is incompatible with strong oxidizing agents, strong acids, or bases.[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 6:1068] **PEER REVIEWED**

中毒表现

造成皮肤刺激，可能导致皮肤过敏反应，怀疑可造成遗传性缺陷（如果最终证明没有其他接触途径会产生这一危害时，应说明其接触途径）。

环境危害

对水生生物有毒并具有长期持续影响。

⑤ 应急处置措施

急救措施

A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with an inhaled beta2-adrenergic agonist. Consider systemic corticosteroids in patients with significant bronchospasm.A) MANAGEMENT OF MILD TO MODERATE TOXICITY 1) Most patients with mild to moderate symptoms may be managed by simple decontamination or removal from exposure and supportive treatment as needed. Treat bronchospasm with inhaled beta2 agonists and systemic corticosteroids. B) MANAGEMENT OF SEVERE TOXICITY 1) Severe toxicity is extremely rare. However, ingestion of polyamine hardeners that are extremely basic may cause severe alkali burns which may require endoscopy to evaluate the extent of injury. In addition, patients with severe respiratory symptoms from organic acid anhydrides may require intubation. C) DECONTAMINATION 1) INGESTION: Gastrointestinal decontamination is not recommended. Ingestion of most epoxy resins or polyamines has low systemic toxicity. Dilution with water or milk may be first line treatment with those with minimal symptoms. For ingestion of polyamine hardeners, endoscopy and more invasive treatment may be needed. 2) INHALATION: Move patient to fresh air and monitor for respiratory distress. Administer oxygen and assist ventilation as needed. Bronchospasm may be treated with inhaled beta2 agonists and oral or parenteral corticosteroids. 3) DERMAL EXPOSURE: Decontaminate skin or mucous membranes immediately with water and a soft sponge. Medical evaluation may be indicated if irritation or pain persists after decontamination. 4) EYE EXPOSURE: Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation or photophobia persists, evaluation from a healthcare professional may be needed. D) AIRWAY MANAGEMENT 1) Rarely necessary but should be considered in patients with concern for upper airway burns or worsening respiratory distress. E) ANTIDOTE 1) None. F) PATIENT DISPOSITION 1) HOME CRITERIA: Patients with minimal or no symptoms after inadvertent exposures may be observed at home. 2) OBSERVATION CRITERIA: Patients who are suicidal or with persistent or worsening symptoms should be sent to a healthcare facility for observation until symptoms are stable or improved. 3) ADMISSION CRITERIA: Patients with persistent or worsening symptoms despite a period of observation or treatment should be admitted to the hospital, and may require ICU admission if symptoms are especially severe (eg, respiratory distress requiring intubation, severe alkali burns from ingestion). Patients should remain in the hospital until stable and clearly improving. 4) CONSULT CRITERIA: Consult a medical toxicologist or poison center for any patient with severe effects or in whom the diagnosis is unclear. In addition, patients with esophageal burns may require consultation from gastroenterology for endoscopy or general surgery for operative exploration or repair. Manufacturers may be contacted for MSDS and potentially other respiratory data concerning their products. G) PITFALLS 1) Unfamiliarity with these compounds may result on over-aggressive or a lack of appreciation of potential complications with certain exposures (eg, caustic alkali burns from polyamine hardeners or hepatitis from methylenedianiline). H) TOXICOKINETICS 1) Epoxy resins and polyamines may cause burns to skin within an hour following exposure. I) DIFFERENTIAL DIAGNOSIS 1) Dermatologic irritation can mimic other substances that can cause a contact dermatitis, including poison ivy and metal allergies. Respiratory symptoms may mimic other irritant gases.A) OVERVIEW 1) Decontaminate skin or mucous membranes immediately with water and a soft sponge. A physician may need to examine the exposed area if irritation or pain persists after the area is washed.A) DECONTAMINATION: Remove contact lenses and irrigate exposed eyes with copious amounts of room temperature 0.9% saline or water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist after 15 minutes of irrigation, the patient should be seen in a healthcare facility.

泄漏应急处理

小量泄漏:用砂土或其他不燃材料吸收。使用洁净的无火花工具收集吸收材料。大量泄漏:构筑围堤或挖坑收容。用泡沫覆盖,减少蒸发。用防爆泵转移至槽车或专用收集器内。

灭火方法

Dry Chemical, foam, carbon dioxide.[U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.] **PEER REVIEWED**

⑥ 安全技术说明书

该物质在登记平台未登记 SDS 文件。

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